Tag Archive for: Obesity

Atrogi announces positive human data for ATR-258, its first-in-class, oral therapy designed to improve muscle function and body composition

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In the 8-week study, ATR-258 was well-tolerated and associated with an approximately 13% mean improvement in lower extremity muscle power in combination with a beneficial effect on body composition, with an increase in lean muscle mass and a reduction in fat mass Data provide first human proof-of-mechanism and support Atrogi’s planned Phase 2 trial expected […]

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Hot topic: Can obesity science help tackle anorexia?

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 Here’s a novel thought: could the science that has enabled us to develop obesity drugs, be repurposed to help people put on weight?  Now, the vast majority of us don’t, of course, need to put on weight.  But some people do – notably many individuals with eating disorders such as anorexia nervosa.  In a ‘Perspectives’ paper recently published in the New England Journal of Medicine, and an […]

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Atrogi announces Cell paper highlighting transformative potential of muscle-targeted therapy in metabolic disease

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Atrogi’s breakthrough discovery enables chronic use of next-generation, highly selective β2-agonists for the first time in metabolic disease First-in-class oral therapy ATR-258 mimics the effects of exercise – driving fat loss, increasing muscle, and improving metabolism – with broad potential in obesity, diabetes, and age-related muscle loss ATR-258 is set to enter Phase 2 trials […]

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Hot topic: What if weight loss drugs are just the first longevity game-changers?

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Back in mid-January Optimum’s Hot Topics column took a look at life expectancy data and asked the rather depressing question: “Will you live longer than your parents – or not?”  Why so downbeat? Because besides stalling life expectancy figures, a slew of other data also seemed to hint that longevity might have peaked: steadily growing […]

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Hot topic: JPM shines bright amid the January gloom

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2025 has already begun with drama in the U.S., as Los Angeles recovers from deadly wildfires and Donald Trump is sworn in for his second presidency. And so it was that the mood going into the annual JP Morgan Healthcare Conference was clouded by uncertainty. With its timing in January, JPM is often seen as […]

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